Centre de RMN à Haut Champ du Québec et de l'Est du Canada

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Publications
  Conformation of the cell division regulator MinE: evidence for interactions between the topological specificity and anti-MinCD domains. Ramos D, Ducat T, Cheng J, Eng NF, Dillon JA, Goto NK. Biochemistry. 2006, 45(14):4593-4601.
  RNA recognition by the Vts1p SAM domain. Johnson PE, Donaldson LW. Nat Struct Mol Biol. 2006, 13(2):177-178.
  Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K. Biochemistry. 2006, 45(7):2250-2256.
  Structural Characterization of the Antimicrobial Peptide Pleurocidin from Winter Flounder. Syvitski RT, Burton I, Douglas S, Mattatall N, Jakeman DL. Biochemistry. 2005, 44(19): 7282-7293.
  The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins. Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW. J Mol Biol. 2006, 356(2):274-279.
  Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. Lim NS, Kozlov G, Chang TC, Groover O, Siddiqui N, Volpon L, De Crescenzo G, Shyu AB, Gehring K. J Biol Chem. 2006, 281(20):14376-14382.
  Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Di Lello P, Jenkins LM, Jones TN, Nguyen BD, Hara T, Yamaguchi H, Dikeakos JD, Appella E, Legault P, Omichinski JG. Mol Cell. 2006, 22(6):731-740.
  Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata. Ngameni B, Touaibia M, Patnam R, Belkaid A, Sonna P, Ngadjui BT, Annabi B, Roy R. Phytochemistry. 2006, 67:2573-2579.
  Crystal structure of the bb' domains of the protein disulfide isomerase ERp57. Kozlov G, Maattanen P, Schrag JD, Pollock S, Cygler M, Nagar B, Thomas DY, Gehring K. Structure. 2006, 14(8):1331-1339.
  1H, 13C and 15N resonance assignments of the catalytic domain of the goldfish RICH protein. Denisov AY, Kozlov G, Gravel M, Sprules T, Braun PE, Gehring K. J Biomol NMR. 2006, 36 Suppl 1:75.
  NMR assignment of human eukaryotic translation initiation factor 4E (eIF4E) in its cap-free form. Volpon L, Osborne MJ, Borden KL. J Biomol NMR. 2006, 36 Suppl 1:65.
  Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands. Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KL. EMBO J. 2006, 25(21):5138-5149.
  Solid-phase synthesis and CD spectroscopic investigations of novel beta-peptides from L-aspartic acid and beta-amino-L-alanine. Ahmed S, Beleid R, Sprules T, Kaur K. Org Lett. 2007, 9(1):25-28.
  The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function. Edmonds L, Liu A, Kwan JJ, Avanessy A, Caracoglia M, Yang I, Maxwell KL, Rubenstein J, Davidson AR, Donaldson LW. J Mol Biol. 2007, 365(1):175-186.
  Heat-induced dimerization of BCL-xL through alpha-helix swapping. Denisov AY, Sprules T, Fraser J, Kozlov G, Gehring K. Biochemistry. 2007, 46(3):734-740.
  Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a). Chitayat S, Kanelis V, Koschinsky ML, Smith SP. Biochemistry. 2007, 46(7):1732-1742.
  InGaP@ZnS-enriched chitosan nanoparticles: A new versatile fluorescent
probe for deep tissue imaging. Sandros M, Behrendt M, Maysinger D, Tabrizian M. Advanced Functional Materials. 2007, 17(18):3724-3730.
  Synthesis of glycodendrimers containing both fucoside and galactoside residues and their
binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa. Deguise I, Lagnoux D, Roy R. New J. Chem. 2007, 31:1321-1331.
  NMR structure of YcgL, a conserved protein from Escherichia coli representing the DUF709 family, with a novel alpha/beta/alpha sandwich fold. Minailiuc OM, Vavelyuk O, Gandhi S, Hung MN, Cygler M, Ekiel I. Proteins. 2007, 66(4):1004-1007.
  Solution structure of the catalytic domain of RICH protein from goldfish. Kozlov G, Denisov AY, Pomerantseva E, Gravel M, Braun PE, Gehring K. FEBS J. 2007, 274(6):1600-1609.
  NMR Assignment of backbone and side chain resonances for a dockerin-containing C-terminal fragment of the putative μ-toxin from Clostridium perfringens. Chitayat, S., Adams, J. J., Smith, S. P. Biomol. NMR Assign. 2007, 1(1):13-15.
  Solution structure of the PABC domain from wheat poly (A)-binding protein: an insight into RNA metabolic and translational control in plants. Siddiqui N, Osborne MJ, Gallie DR, Gehring K. Biochemistry. 2007, 46(14):4221-4231.
  Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. Siddiqui N, Mangus DA, Chang TC, Palermino JM, Shyu AB, Gehring K. J Biol Chem. 2007, 282(34):25067-25075.
  Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau. Ngameni B, Touaibia M, Belkaid A, Ambassa P, Watchueng J, Patnam R, Ngadjui BT, Annabi B, Roy R. ARKIVOC. 2007, ix:91-103.
  Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M. J Biol Chem. 2007, 282(37):27547-27555.
  The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, Denisov AY, Philie J, Allaire PD, Legendre-Guillemin V, Zylbergold P, Gehring K, McPherson PS. EMBO J. 2007, 26(18):4066-4077.
  The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB. Beribisky AV, Tavares TJ, Amborski AN, Motamed M, Johnson AE, Mark TL, Johnson PE. RNA. 2007, 13(11):1948-1956.
  Stabilized recombinant suppressors of RNA silencing: functional effects of linking monomers of Carnation Italian Ringspot virus p19. Cheng J, Sagan SM, Assem N, Koukiekolo R, Goto NK, Pezacki JP. Biochim Biophys Acta. 2007, 1774(12):1528-1535.
  Structural basis of ubiquitin recognition by the UBA domain of the ubiquitin ligase EDD. Kozlov G, Nguyen L, Lin T, De Crescenzo G, Park M, Gehring K. J Biol Chem. 2007, 282(49):35787-35795.
  Coordination properties of Cu(II) and Ni(II) ions towards the C-terminal peptide fragment -TYTEHA- of histone H4. Karavelas T, Malandrinos G, Hadjiliadis N, Mlynarz P, Kozlowski H, Barsan M, Butler I. Dalton Trans. 2008, (9):1215-1223.
  Right-handed 14-helix in beta 3-peptides from L-aspartic acid monomers. Kaur K, Sprules T, Soliman W, Beleid R, Ahmed S. Biochim Biophys Acta. 2008, 1784(4):658-665.
  Nuclear magnetic resonance solution structure of PisI, a group B immunity protein that provides protection against the type IIa bacteriocin piscicolin 126, PisA. Martin-Visscher LA, Sprules T, Gursky LJ, Vederas JC. Biochemistry. 2008, 47(24):6427-6436.
  Hemisynthesis and spectroscopic characterization of three glycosylated 4 hydrocylonchocarpins from Dorstenia barteri Bureau. Ngameni B, Patnam R, Sonna P, Ngadjui BT, Roy R, Abegazd BM. ARKIVOC. 2008, vi:152-159.
  Control of DNA incorporation into nanoparticles with poly-L-lysine multilayers. Dorris A, Douglas K, Tabrizian M, Barett C. The Canadian Journal of Chemistry. 2008, 86(12):1085-1094.
  The solution structure of the C-terminal modular pair from Clostridium perfringens mu-toxin reveals a noncellulosomal dockerin module. Chitayat S, Adams JJ, Furness HS, Bayer EA, Smith SP. J Mol Biol. 2008, 381(5):1202-1212.
  The solution structure of the C-terminal modular pair from Clostridium perfringens mu-toxin reveals a noncellulosomal dockerin module. Chitayat S, Adams JJ, Furness HS, Bayer EA, Smith SP. J Mol Biol. 2008, 381(5):1202-1212.
  Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies. Sydow-Plum G, Haidar ZS, Merhi Y, Tabrizian M. Materials. 2008, 1(1), 25-43.
  Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Seli E, Botros L, Sakkas D, Burns DH. Fertil Steril. 2008, 90(6):2183-2189.
  Design and Synthesis of Androgen Receptor Antagonists with Bulky Side Chains for Overcoming Antiandrogen Resistance
By Zhou, Jinming; Geng, Guoyan; Shi, Qingwen; Sauriol, Francoise; Wu, Jian Hui
From Journal of Medicinal Chemistry (2009), 52(17), 5546-5550.
  Syntheses and potential anti-prostate cancer activities of ionone-based chalcones
By Zhou, Jinming; Geng, Guoyan; Batist, Gerald; Wu, Jian Hui
From Bioorganic & Medicinal Chemistry Letters (2009), 19(4), 1183-1186.
  Atypical binding of the Swa2p UBA domain to ubiquitin. Matta-Camacho E, Kozlov G, Trempe JF, Gehring K. J Mol Biol. 2009, 386(2):569-577.
  Solution structure of the bb' domains of human protein disulfide isomerase. Denisov AY, Määttänen P, Dabrowski C, Kozlov G, Thomas DY, Gehring K. FEBS J. 2009, 276(5):1440-1449.
  Binding mechanism of an SH3 domain studied by NMR and ITC. Demers JP, Mittermaier A. J Am Chem Soc. 2009 Apr 1;131(12):4355-67.
  Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG. Proc Natl Acad Sci U S A. 2009, 106(18):7408-7413.
  Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. Tavares TJ, Beribisky AV, Johnson PE. RNA. 2009, 15(5):911-922.
  NMR dynamics of PSE-4 beta-lactamase: an interplay of ps-ns order and μs-ms motions in the active site. Morin S, Gagné SM. Biophys J. 2009, 96(11):4681-4691.
  13 C NMR as a primary method for determining saturates, cis- and trans-monounsaturates and polyunsaturates in fats and oils for nutritional labeling purposes. Gao L, Sedman J, García-González DL, Ehsan S, Sprules T, van de Voort FR. Eur. J. Lipid Sci. Technol. 2009, 111, 612-622.
  Preparation of 2-alkenylperhydro-1,3-benzoxazines and application for 2-isoxazolines synthesis. Poisson C, Lacoste J-É, Rochon FD, Breau L. Tetrahedron:Asymmetry 2009, 20(21): 2447-2461.
  The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system. Pell LG, Kanelis V, Donaldson LW, Howell PL, Davidson AR. Proc Natl Acad Sci U S A. 2009, 106(11):4160-5.
  SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Trempe JF, Chen CX, Grenier K, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA. Mol Cell. 2009, 36(6):1034-47.
  Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity. Tong W, Gagnon M, Sprules T, Gilbert M, Chowdhury S, Meerovitch K, Hansford K, Purisima EO, Blankenship JW, Cheung NK, Gehring K, Lubell WD, Saragovi HU, Chem. Biol. 2010, 17, 183-194.
  Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E. Volpon L, Osborne MJ, Capul AA, de la Torre JC, Borden KL. Proc Natl Acad Sci U S A. 2010, 107(12):5441-6.
  Analyzing protein folding cooperativity by differential scanning calorimetry and NMR spectroscopy. Farber P, Darmawan H, Sprules T, Mittermaier A. J Am Chem Soc. 2010, 132(17):6214-22.
  Metabolite composition and bioactivity of Rhizoctonia solani sclerotial exudates. Aliferis KA, Jabaji S. J Agric Food Chem. 2010, 58(13):7604-15.
  Apoptotic regulation by MCL-1 through hetero-dimerization. Liu Q, Moldoveanu T, Sprules T, Matta-Camacho E, Mansur-Azzam N, Gehring K. J Biol Chem. 2010, 285(25):19615-24.
  Protein alignment using cellulose nanocrystals: practical considerations and range of application. Denisov AY, Kloser E, Gray DG, Mittermaier AK. J Biomol NMR. 2010, 47(3):195-204.
  Appropriation of the MinD protein-interaction motif by the dimeric interface of the bacterial cell division regulator MinE. Ghasriani H, Ducat T, Hart CT, Hafizi F, Chang N, Al-Baldawi A, Ayed SH, Lundström P, Dillon JA, Goto NK. Proc Natl Acad Sci U S A. 2010, 107(43):18416-21.
  Defining a Stem Length-Dependent Binding Mechanism for the Cocaine-Binding Aptamer. A Combined NMR and Calorimetry Study. Neves MA, Reinstein O, Johnson PE. Biochemistry. Oct 5;49(39):8478-87 2010
  Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.
De Schutter JW, Zaretsky S, Welbourn S, Pause A, Tsantrizos YS.
Bioorg Med Chem Lett. 2010 Oct 1;20(19):5781-6.
  The solution structure of the C-terminal Ig-like domain of the bacteriophage λ tail tube protein. Pell LG, Gasmi-Seabrook GM, Morais M, Neudecker P, Kanelis V, Bona D, Donaldson LW, Edwards AM, Howell PL, Davidson AR, Maxwell KL. J Mol Biol. 2010, 403(3):468-79.
  Ligand specificity in fragment-based drug design. Barelier S, Pons J, Gehring K, Lancelin JM, Krimm I. J Med Chem. 2010,53(14):5256-66.
  1H, 13C, 15N chemical shift assignments for the Neisseria gonorrhoeae MinE regulator of cell division septum placement. Ducat T, Goto NK. Biomol NMR Assign. 2010 Oct;4(2):227-9.
  Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants
By Zhou, Jinming; Geng, Guoyan; Wu, Jian Hui
From Investigational New Drugs (2010), 28(3), 291-298.
  Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens. Zhou J, Liu B, Geng G, Wu JH. Proteins. 2010 Feb 15;78(3):623-37.
  Determining nutritional labeling data for fats and oils by 1H NMR. Sedman J, Gao L, García-González D, Ehsan S, van de Voort, FR. Eur. J. Lipid Sci. Technol., 2010, 112:439–451.
  Concerted dynamics link allosteric sites in the PBX homeodomain. Farber PJ, Mittermaier A. J Mol Biol. 2011 Jan 21;405(3):819-30.
  Lee A Freiburger, Oliver M Baettig, Tara Sprules, Albert M Berghuis, Karine Auclair, Anthony K Mittermaier
Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.
Nature Structural & Molecular Biology 18, 288–294 (2011)
  Riboswitch structure: an internal residue mimicking the purine ligand.
Delfosse V, Bouchard P, Bonneau E, Dagenais P, Lemay JF, Lafontaine DA, Legault P.Nucleic Acids Res. 2010 Apr;38(6):2057-68.